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The distinct lack of polar interactions or engagement of R471 are in stark contrast to the interactions observed in the occluded structure

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And regulatory approvals already reflect this shift: Wegovy is approved to lower cardiovascular risk, Ozempic slows kidney disease progression, and semaglutide is cleared for metabolic dysfunctionassociated steatohepatitis (MASH) with fibrosis

Renal histopathology Mouse kidney samples were fixed in 4% paraformaldehyde overnight and embedded in paraffin

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